The OCR GCSE Biology Paper 1 (June 2022) focuses on cell biology, DNA structure, photosynthesis, respiration, and human circulatory and endocrine systems. Key topics include mitosis, enzyme activity, auxins, reflex arcs, and homeostasis. Practical investigations explore light intensity′s effect on photosynthesis, water loss in plants, and enzyme activity. The paper emphasizes data interpretation, experimental methods, and biological processes such as diabetes management, menstrual cycle regulation, and thermoregulation during hypothermia. Ethical considerations, including the use of stem cells, are also addressed.