The OCR GCSE Biology Paper 1 (November 2021) covers fundamental biology topics such as DNA, respiration, the immune system, and plant tropisms. Key areas include enzyme activity, genetic inheritance, and biodiversity. The paper integrates practical investigations, such as testing for photosynthesis and examining pathogen transmission. Human health topics include disease prevention, the role of vaccinations, and selective breeding for food security. Ethical considerations in genetic research, data interpretation, and real-world biological applications, like carbon neutrality in biofuels, are emphasized. Analytical and experimental skills are central to understanding biological systems and their implications.