The November 2020 OCR Science GCSE Paper 8 evaluates advanced biology topics, including genetic variation, natural selection, and environmental cycling. Key areas of focus include the human genome project, genetic engineering, mutualism, parasitism, and cardiovascular treatments. Practical applications like sampling in ecological studies, analyzing photosynthesis, and investigating HPV vaccination impacts are included. Students interpret data from phylogenetic trees, analyze abiotic and biotic interactions, and explore the nitrogen cycle. Keywords: GCSE Biology, genetic variation, natural selection, mutualism, ecosystem dynamics, photosynthesis, nitrogen cycle, HPV vaccination.